Title : Metformin Promotes Neuronal Differentiation via Crosstalk between Cdk5 and Sox6 in Neuroblastoma Cells.

Pub. Date : 2019

PMID : 30911317






2 Functional Relationships(s)
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1 In addition, phosphorylated Erk1/2 was decreased while phosphorylated Akt was increased in metformin treatment. Metformin mitogen-activated protein kinase 3 Homo sapiens
2 Taken together, these findings suggest that metformin promotes neuronal differentiation via ROS activation through Cdk5/Sox6 crosstalk, relating to Erk1/2 and Akt signaling. Metformin mitogen-activated protein kinase 3 Homo sapiens