Title : Calcium-calmodulin gating of a pH-insensitive isoform of connexin43 gap junctions.

Pub. Date : 2019 Apr 10

PMID : 30910801






3 Functional Relationships(s)
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Protein Name
Organism
1 The addition of 1 muM ionomycin to normal calcium saline reduced Cx43 or Cx43-M257 g j to zero within 15 min of perfusion. Ionomycin gap junction protein, alpha 1 Mus musculus
2 The addition of 1 muM ionomycin to normal calcium saline reduced Cx43 or Cx43-M257 g j to zero within 15 min of perfusion. Ionomycin gap junction protein, alpha 1 Mus musculus
3 Internal addition of a connexin50 cytoplasmic loop calmodulin-binding domain (CaMBD) mimetic peptide (200 nM) prevented the Ca2+/ionomycin-induced decrease in Cx43 g j, while 100 muM Gap19 peptide had minimal effect. Ionomycin gap junction protein, alpha 1 Mus musculus