Title : Dearomatization-Rearomatization Strategy for Reductive Cross-Coupling of Indoles with Ketones in Water.

Pub. Date : 2019 Apr 5

PMID : 30908058






1 Functional Relationships(s)
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1 Using ketones as N-alkylation reagent for indoles has been a great challenge not only because of the competing alkylation reaction of C-3 position but also because of the poor nucleophilicity of the nitrogen atom of indole, in addition to the steric hindrance and lower electrophilicity of the ketones. Nitrogen complement C3 Homo sapiens