Pub. Date : 2019
PMID : 30906223
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Astragaloside IV Suppresses High Glucose-Induced NLRP3 Inflammasome Activation by Inhibiting TLR4/NF-kappaB and CaSR. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | The results showed that high glucose increased the expression of interleukin-18 (IL-18), interleukin-1beta (IL-1beta), NLRP3, caspase-1, and ASC, as well as the protein level of TLR4, nucleus p65, and CaSR. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Meanwhile, NPS2143, BAY 11-7082, and INF39 could significantly abolish the high glucose-enhanced NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression in vitro. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | In addition, both NPS2143 and BAY 11-7082 attenuated high glucose-induced upregulation of NLRP3, ASC, caspase-1, IL-18, and IL-1beta expression. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | In conclusion, this study suggested that As-IV could inhibit high glucose-induced NLRP3 inflammasome activation and subsequent secretion of proinflammatory cytokines via inhibiting TLR4/NF-kappaB signaling pathway and CaSR, which provides new insights into the anti-inflammatory activity of As-IV. | Glucose | NLR family pyrin domain containing 3 | Homo sapiens |