Pub. Date : 2019 Jun 15
PMID : 30902657
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Farnesoid X receptor agonist GW4064 indirectly inhibits HCV entry into cells via down-regulating scavenger receptor class B type I. Farnesoid X receptor (FXR) agonists play important regulatory roles in bile acid, lipid and glucose metabolism in vitro and in vivo. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 2 | This study investigated the effect and mechanism of FXR agonist GW4064 against HCV in vitro to explore the potential application of FXR agonists. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |
| 3 | GW4064 down-regulated the expression of scavenger receptor class B type I protein via FXR and thereby indirectly inhibited HCV entry into cells, leading to interruption of HCV life cycle. | GW 4064 | nuclear receptor subfamily 1 group H member 4 | Homo sapiens |