Title : Impact of cytochrome P450 variation on meperidine N-demethylation to the neurotoxic metabolite normeperidine.

Pub. Date : 2020 Feb

PMID : 30902024






2 Functional Relationships(s)
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1 In CYP2C19-genotyped human liver microsomes, normeperidine formation was significantly correlated with CYP2C19 activity (S-mephenytoin 4 -hydroxylation). Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens
2 In CYP2C19-genotyped human liver microsomes, normeperidine formation was significantly correlated with CYP2C19 activity (S-mephenytoin 4 -hydroxylation). Mephenytoin cytochrome P450 family 2 subfamily C member 19 Homo sapiens