Pub. Date : 2019
PMID : 30899369
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin induces the M2 macrophage polarization to accelerate the wound healing via regulating AMPK/mTOR/NLRP3 inflammasome singling pathway. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | We also found that the level of relative proteins of NLRP3 inflammasome was markedly decreased after metformin treatment. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | Furthermore, blockage of AMPK or activation of mTOR abolished the effects of metformin treatment on depressing NLRP3 inflammasome activation, M2 polarization and improving wound healing. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | It suggested that the treatment effects of metformin on wound healing were through regulating AMPK/mTOR/NLRP3 inflammasome signaling axis. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | CONCLUSION: Metformin regulated AMPK/mTOR singling pathway to inhibit NLRP3 inflammasome activation, which boosted M2 macrophage polarization to accelerate the wound healing. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |