Pub. Date : 2019
PMID : 30899201
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase. | Capsaicin | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 2 | In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin. | Capsaicin | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |
| 3 | In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin. | Capsaicin | protein kinase AMP-activated catalytic subunit alpha 1 | Homo sapiens |