Title : Icariin protects vascular endothelial cells from oxidative stress through inhibiting endoplasmic reticulum stress.

Pub. Date : 2019 May

PMID : 30890424






3 Functional Relationships(s)
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1 ERS activators H2O2 and dl-dithiothreitol (DTT) significantly increased GRP78, ATF4 and eIF2alpha expressions, decreased cell activity and reduced SOD and GSH-Px activity. Hydrogen Peroxide heat shock protein family A (Hsp70) member 5 Homo sapiens
2 In contrast, the H2O2 + 100 mumol/L ICA and H2O2 + 100 mumol/L ICA + DTT groups had significant inhibitory effects on the expressions of GRP78, ATF4 and eIF2alpha proteins, showing enhanced cell viability and SOD and GSH-Px activity. Hydrogen Peroxide heat shock protein family A (Hsp70) member 5 Homo sapiens
3 In contrast, the H2O2 + 100 mumol/L ICA and H2O2 + 100 mumol/L ICA + DTT groups had significant inhibitory effects on the expressions of GRP78, ATF4 and eIF2alpha proteins, showing enhanced cell viability and SOD and GSH-Px activity. Hydrogen Peroxide heat shock protein family A (Hsp70) member 5 Homo sapiens