Title : Effects of Aspirin on Growth Factor Release From Freshly Isolated Leukocyte-Rich Platelet-Rich Plasma in Healthy Men: A Prospective Fixed-Sequence Controlled Laboratory Study.

Pub. Date : 2019 Apr

PMID : 30888847






4 Functional Relationships(s)
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1 PURPOSE:: To assess the effects of low-dose ASA use on activation of growth factor release from freshly isolated human PRP via AA and thrombin (TBN). Aspirin coagulation factor II, thrombin Homo sapiens
2 PURPOSE:: To assess the effects of low-dose ASA use on activation of growth factor release from freshly isolated human PRP via AA and thrombin (TBN). Aspirin coagulation factor II, thrombin Homo sapiens
3 Although ASA had no effect on TBN-mediated release of VEGF and TGF-beta1 from LR-PRP, ASA did partially block TBN-mediated release of PDGF-AB, although the mechanism remains unclear. Aspirin coagulation factor II, thrombin Homo sapiens
4 CLINICAL RELEVANCE:: Reduction in growth factor release attributed to daily use of low-dose ASA or other COX inhibitors can be mitigated when PRP samples are activated with TBN. Aspirin coagulation factor II, thrombin Homo sapiens