Title : Presence of glycoproteins containing the polylactosamine structure in brain and liver of GM1 gangliosidosis patients. Comparative study between clinical types I and II, using endo-beta-galactosidase enzyme.

Pub. Date : 1986 Apr

PMID : 3088498






2 Functional Relationships(s)
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1 Treatment with endo-beta-galactosidase showed that the stored material contained N-acetyllactosamine repeating units. N-acetyllactosamine galactosidase beta 1 Homo sapiens
2 Treatment with exo-beta-galactosidase transformed the trisaccharide OS II into the disaccharide OS I, indicating that the deficiency of beta-galactosidase in GM1 gangliosidosis type I, but not in type II, also affects glycoprotein catabolism, leading to the accumulation of glycopeptides containing terminal beta-galactosyl residues and N-acetyllactosamine repeating units. N-acetyllactosamine galactosidase beta 1 Homo sapiens