Title : Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP+ binding.

Pub. Date : 2019 Apr

PMID : 30883732






4 Functional Relationships(s)
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Sentence
Compound Name
Protein Name
Organism
1 Heme oxygenase-1 (HMOX1) catalyzes heme degradation utilizing reducing equivalents supplied from NADPH-cytochrome P450 reductase (CYPOR). Heme heme oxygenase 1 Homo sapiens
2 Heme oxygenase-1 (HMOX1) catalyzes heme degradation utilizing reducing equivalents supplied from NADPH-cytochrome P450 reductase (CYPOR). Heme heme oxygenase 1 Homo sapiens
3 As a result of this change, the FMN-binding domain of CYPOR approaches heme-bound HMOX1 upon NADP+ binding to enhance the electron-transfer efficiency from FMN to heme. Heme heme oxygenase 1 Homo sapiens
4 As a result of this change, the FMN-binding domain of CYPOR approaches heme-bound HMOX1 upon NADP+ binding to enhance the electron-transfer efficiency from FMN to heme. Heme heme oxygenase 1 Homo sapiens