Title : Construction of a GLUT-1 and HIF-1α gene knockout cell model in HEp-2 cells using the CRISPR/Cas9 technique.

Pub. Date : 2019

PMID : 30881132






1 Functional Relationships(s)
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1 The possible mechanism may be that the inhibition PI3K/AKT/mTOR pathway by HIF-1alpha and GLUT-1 double gene knockout using CRISPR/Cas9 technique lead to reduction of glucose uptake and lactic acid generation. Lactic Acid mechanistic target of rapamycin kinase Homo sapiens