Pub. Date : 2019 Jun 15
PMID : 30880181
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Comparative study of carvedilol and quinidine for inhibiting hKv4.3 channel stably expressed in HEK 293 cells. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 2 | It was found that carvedilol and quinidine inhibited hKv4.3 current in a concentration-dependent manner. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 3 | Both carvedilol and quinidine showed typical open channel blocking properties (i.e. decreasing the time to peak of activation and increasing the inactivation of hKv4.3), negatively shifted the V1/2 of activation and inactivation, and slowed the recovery from inactivation of the channel. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |
| 4 | These results provide the novel information that carvedilol, like quinidine, significantly inhibits hKv4.3 and action potential notch, suggesting that carvedilol is likely an alternative drug for preventing malignant ventricular arrhythmias in patients with Brugada syndrome in countries where quinidine is unavailable. | Quinidine | potassium voltage-gated channel subfamily D member 3 | Homo sapiens |