Title : Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping.

Pub. Date : 2019 Dec

PMID : 30879350






2 Functional Relationships(s)
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1 Discovery of novel coumarin derivatives as potent and orally bioavailable BRD4 inhibitors based on scaffold hopping. coumarin bromodomain containing 4 Homo sapiens
2 Starting from scaffold hopping of the reported compound dihydroquinazolinone (PFI-1), a series of coumarin derivatives were designed and synthesised as a new chemotype of BRD4 inhibitors. coumarin bromodomain containing 4 Homo sapiens