Title : Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.

Pub. Date : 2019 Apr

PMID : 30878890






2 Functional Relationships(s)
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Protein Name
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1 Compounds 3b-g exhibited superior inhibitory activity than celecoxib as COX-2 inhibitors. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens
2 Compounds 3b-d and 3g were the most potent COX-2 inhibitors with IC50 range of 6.4 - 8.13 nM and higher selectivity indexes (3b, SI = 26.19; 3c, SI = 13.73; 3d, SI = 29.27; 3g, SI = 18.00) comparing to celecoxib (IC50 = 42.60 nM, SI = 8.05). Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens