Pub. Date : 2019 Mar 13
PMID : 30867420
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This Abeta-induced suppression of Pr is mainly due to an mGluR5-mediated depletion of phosphatidylinositol-4,5-bisphosphate (PIP2) in axons. | Phosphatidylinositol 4,5-Diphosphate | amyloid beta (A4) precursor protein | Mus musculus |
| 2 | This Abeta-induced suppression of Pr is mainly due to an mGluR5-mediated depletion of phosphatidylinositol-4,5-bisphosphate (PIP2) in axons. | Phosphatidylinositol 4,5-Diphosphate | amyloid beta (A4) precursor protein | Mus musculus |
| 3 | Selectively inhibiting Abeta-induced PIP2 hydrolysis in the CA3 region of the hippocampus strongly prevents oligomeric Abeta-induced suppression of Pr at the SC-CA1 synapse and rescues synaptic and spatial learning and memory deficits in APP/PS1 mice. | Phosphatidylinositol 4,5-Diphosphate | amyloid beta (A4) precursor protein | Mus musculus |
| 4 | Selectively inhibiting Abeta-induced PIP2 hydrolysis in the CA3 region of the hippocampus strongly prevents oligomeric Abeta-induced suppression of Pr at the SC-CA1 synapse and rescues synaptic and spatial learning and memory deficits in APP/PS1 mice. | Phosphatidylinositol 4,5-Diphosphate | amyloid beta (A4) precursor protein | Mus musculus |
| 5 | These results first reveal the presynaptic mGluR5-PIP2 pathway whereby oligomeric Abeta induces early synaptic deficits in AD. | Phosphatidylinositol 4,5-Diphosphate | amyloid beta (A4) precursor protein | Mus musculus |