Pub. Date : 2019 Mar 12
PMID : 30866966
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We also found that low levels of pyruvate contributed to proliferation of CCA cells and confirmed that the upstream target is cMyc. | Pyruvic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | Conversely, high activity of HDAC3 stabilized cMyc protein by preferential deacetylating cMyc at K323 site, which further contributed to the low pyruvate levels. | Pyruvic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | Conversely, high activity of HDAC3 stabilized cMyc protein by preferential deacetylating cMyc at K323 site, which further contributed to the low pyruvate levels. | Pyruvic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | CONCLUSIONS: Collectively, our findings identify a role for promoting the low pyruvate levels regulated by c-Myc, and its dynamic acetylation in cancer cell proliferation. | Pyruvic Acid | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |