Pub. Date : 2019 Mar 12
PMID : 30866966
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The purpose of our study was to explore the role of cMyc in regulating pyruvate metabolism, as well as to investigate whether the inhibitory effect of pyruvate on HDAC3 could hold promise in the treatment of cancer cells. | Pyruvic Acid | histone deacetylase 3 | Homo sapiens |
| 2 | Downregulated pyruvate levels decreased the inhibition to HDAC3 and consequently protected CCA cells from apoptosis. | Pyruvic Acid | histone deacetylase 3 | Homo sapiens |
| 3 | Conversely, high activity of HDAC3 stabilized cMyc protein by preferential deacetylating cMyc at K323 site, which further contributed to the low pyruvate levels. | Pyruvic Acid | histone deacetylase 3 | Homo sapiens |