Pub. Date : 2019 May 1
PMID : 30865562
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Stretching magnitude-dependent inactivation of AKT by ROS led to enhanced p53 mitochondrial translocation and myoblast apoptosis. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 2 | Furthermore, we demonstrated that overaccumulation of reactive oxygen species (ROS) during HMS-inactivated AKT that was activated in LMS-treated cells, which accounted for the distinct p53 subcellular localizations under HMS and LMS. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 3 | Furthermore, we demonstrated that overaccumulation of reactive oxygen species (ROS) during HMS-inactivated AKT that was activated in LMS-treated cells, which accounted for the distinct p53 subcellular localizations under HMS and LMS. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 4 | Blocking ROS generation by N-acetylcysteine (NAC) or overexpressing constitutively active AKT vector (CA-AKT) inhibited HMS-incurred p53 mitochondrial translocation and promoted its nuclear targeting. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 5 | Finally, we found that Ser389 phosphorylation of p53 was a downstream event of ROS-inactivated AKT pathway, which was critical to p53 mitochondrial trafficking during HMS stimuli. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 6 | Finally, we found that Ser389 phosphorylation of p53 was a downstream event of ROS-inactivated AKT pathway, which was critical to p53 mitochondrial trafficking during HMS stimuli. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 7 | Altogether, our study uncovered that mitochondrial localization of p53, resulting from p53 Ser389 phosphorylation through ROS-inactivated AKT pathway, prompted C2C12 myoblast apoptosis during HMS stimulation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |
| 8 | Altogether, our study uncovered that mitochondrial localization of p53, resulting from p53 Ser389 phosphorylation through ROS-inactivated AKT pathway, prompted C2C12 myoblast apoptosis during HMS stimulation. | Reactive Oxygen Species | tumor protein p53 | Homo sapiens |