Title : Pharmacological Manipulation of Trk, p75NTR, and NGF Balance Restores Memory Deficit in Global Ischemia/Reperfusion Model in Rats.

Pub. Date : 2019 May

PMID : 30863991






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 GM1 stimulates the release of nerve growth factor (NGF), which is synthesized as a precursor protein (pro-NGF) that either mediates apoptosis through the p75 neurotrophin receptor (p75NTR) or is cleaved by the protease furin (FUR) to yield mature NGF, the latter supporting survival through tropomyosin kinase receptor (Trk). G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Rattus norvegicus
2 GM1 increased FUR levels, while concomitant administration of EPI weakened GM1 effect on pro-survival Trk and p75NTR mediators. G(M1) Ganglioside neurotrophic receptor tyrosine kinase 1 Rattus norvegicus