Title : Tyrosine kinase inhibitors vandetanib, lenvatinib and cabozantinib modulate oxidation of an anticancer agent ellipticine catalyzed by cytochromes P450 in vitro.

Pub. Date : 2019 Feb

PMID : 30860683






1 Functional Relationships(s)
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1 OBJECTIVES: Vandetanib lenvatinib, and cabozantinib are tyrosine kinase inhibitors (TKIs) targeting VEGFR subtypes 1 and 2, EGFR and the RET-tyrosine kinase, thus considered as multiple TKIs. lenvatinib epidermal growth factor receptor Homo sapiens