Title : A role for ATP Citrate Lyase in cell cycle regulation during myeloid differentiation.

Pub. Date : 2019 May

PMID : 30853332






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 ACL is an essential enzyme for generating acetyl-CoA, a key metabolite for the first step in fatty acid synthesis and for histone acetylation. Acetyl Coenzyme A ATP citrate lyase Homo sapiens
2 In this study, we found that acetyl-CoA or acetate supplementation was sufficient to rescue cell cycle progression in cultured BN cells treated with an ACL inhibitor or induced for PU.1 expression. Acetyl Coenzyme A ATP citrate lyase Homo sapiens