Title : Novel tacrine-tryptophan hybrids: Multi-target directed ligands as potential treatment for Alzheimer's disease.

Pub. Date : 2019 Apr 15

PMID : 30851693






1 Functional Relationships(s)
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1 Based on the in vitro biological profile, compound S-K1035 was found to be the most potent inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBChE), demonstrating balanced IC50 values of 6.3 and 9.1 nM, respectively. Sulfur acetylcholinesterase (Cartwright blood group) Homo sapiens