Pub. Date : 2019 Jun 5
PMID : 30851273
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin reduced NLRP3 inflammasome activity in Ox-LDL stimulated macrophages through adenosine monophosphate activated protein kinase and protein phosphatase 2A. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | This research aimed to elucidate whether and how metformin affects NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activity in oxidized low-density lipoprotein (ox-LDL) stimulated macrophages. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 3 | This research aimed to elucidate whether and how metformin affects NLR Family Pyrin Domain Containing 3 (NLRP3) inflammasome activity in oxidized low-density lipoprotein (ox-LDL) stimulated macrophages. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 4 | In the results, upregulation of NLRP3 protein expression and NLRP3 inflammasome activation induced by ox-LDL treatment in macrophages were significantly attenuated by metformin treatment. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 5 | In the results, upregulation of NLRP3 protein expression and NLRP3 inflammasome activation induced by ox-LDL treatment in macrophages were significantly attenuated by metformin treatment. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 6 | Inhibition of PP2A significantly restored NLRP3 and pro-IL-1beta protein expression level downregulated by metformin in ox-LDL-stimulated macrophages. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 7 | Our data showed Metformin reduced NLRP3 protein expression and NLRP3 inflammasome activation in ox-LDL-stimulated macrophages through AMPK and PP2A. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |
| 8 | Our data showed Metformin reduced NLRP3 protein expression and NLRP3 inflammasome activation in ox-LDL-stimulated macrophages through AMPK and PP2A. | Metformin | NLR family pyrin domain containing 3 | Homo sapiens |