Title : Carbon nanotubes and crystalline silica stimulate robust ROS production, inflammasome activation, and IL-1β secretion in macrophages to induce myofibroblast transformation.

Pub. Date : 2019 Apr

PMID : 30847537






1 Functional Relationships(s)
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1 Therefore, fibrogenic CNTs and silica, but not CB, elicit robust macrophage-guided myofibroblast transformation, which depends on the induction of IL-1beta through the NLRP3 inflammasome pathway and the increased production of ROS in macrophages. Silicon Dioxide NLR family pyrin domain containing 3 Homo sapiens