Pub. Date : 2019 Mar 8
PMID : 30846598
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase. | NADP | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP+ and NADPH. | NADP | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | We find that growth factor signaling through the phosphoinositide 3-kinase (PI3K)-Akt pathway induces acute synthesis of NADP+ and NADPH. | NADP | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Akt phosphorylates NAD kinase (NADK), the sole cytosolic enzyme that catalyzes the synthesis of NADP+ from NAD+ (the oxidized form of NADH), on three serine residues (Ser44, Ser46, and Ser48) within an amino-terminal domain. | NADP | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | These data indicate that Akt-mediated phosphorylation of NADK stimulates its activity to increase NADP+ production through relief of an autoinhibitory function inherent to its amino terminus. | NADP | AKT serine/threonine kinase 1 | Homo sapiens |