Title : Unique mechanistic insights into the beneficial effects of angiotensin-(1-7) on the prevention of cardiac fibrosis: A metabolomic analysis of primary cardiac fibroblasts.

Pub. Date : 2019 May 15

PMID : 30844388






1 Functional Relationships(s)
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1 Furthermore, we found that angiotensin-(1-7) suppressed the abnormal calcium- and ROS-dependent activation of calcium/calmodulin-dependent protein kinase II delta (CaMKIIdelta), the increased expression of CaMKIIdelta-related proteins (NADPH oxidase 4 (Nox4), cellular communication network factor 2 (CTGF), and p-ERK1/2), and excessive collagen deposition in vitro and in vivo. Reactive Oxygen Species mitogen-activated protein kinase 3 Homo sapiens