Pub. Date : 2019 May 1
PMID : 30835510
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 2 | Previous studies established that leucine stimulates protein synthesis in skeletal muscle to the same extent as a complete mixture of amino acids, and the effect occurs through activation of the mechanistic target of rapamycin in complex 1 (mTORC1). | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 3 | Recent studies using cells in culture showed that the Sestrins bind leucine and are required for leucine-dependent activation of mTORC1. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 4 | Recent studies using cells in culture showed that the Sestrins bind leucine and are required for leucine-dependent activation of mTORC1. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 5 | The goal of the present study was to compare expression of the Sestrins in skeletal muscle to other tissues and to assess their relative role in mediating activation of mTORC1 by leucine. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |
| 6 | Overall, the results presented herein are consistent with a model in which leucine-induced activation of mTORC1 in skeletal muscle in vivo occurs primarily through release of Sestrin1 from GATOR2. | Leucine | CREB regulated transcription coactivator 1 | Mus musculus |