Title : Combination therapy with dacarbazine and statins improved the survival rate in mice with metastatic melanoma.

Pub. Date : 2019 Aug

PMID : 30834527






1 Functional Relationships(s)
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1 We found that cotreatment with dacarbazine and statins significantly inhibited tumor growth and metastasis via suppression of the RhoA/RhoC/LIM domain kinase/serum response factor/c-Fos pathway and enhanced p53, p21, p27, cleaved caspase-3, and cleaved poly(ADP-ribose) polymerase 1 expression in vivo. Dacarbazine transformation related protein 53, pseudogene Mus musculus