Title : Dietary Polyphenols Protect Against Oleic Acid-Induced Steatosis in an in Vitro Model of NAFLD by Modulating Lipid Metabolism and Improving Mitochondrial Function.

Pub. Date : 2019 Mar 3

PMID : 30832407






1 Functional Relationships(s)
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1 In a model of steatosis using HepG2 hepatocytes, exposure of the cells to 1.5 mM oleic acid (OA) for 24 h caused steatosis and distorted cell morphology, induced the expression of mRNA for enzymes that are involved in lipogenesis and fatty acid oxidation (FAS and CPT1A), and impaired indices of aerobic energy metabolism (PPARgamma mRNA expression, mitochondrial membrane potential (MMP), and galactose-supported ATP production). Oleic Acid peroxisome proliferator activated receptor gamma Homo sapiens