Title : The LPS/D-Galactosamine-Induced Fulminant Hepatitis Model to Assess the Role of Ligand-Activated Nuclear Receptors on the NLRP3 Inflammasome Pathway In Vivo.

Pub. Date : 2019

PMID : 30825154






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Low doses of LPS in combination with the specific hepatotoxic agent D-galactosamine (D-GalN) promote liver injury in mice and induce the production of inflammatory cytokines associated with increased NLRP3 protein and caspase 1 activity, thus recapitulating the clinical picture of FH in humans. Galactosamine caspase 1 Mus musculus