Title : Src in endosomal membranes promotes exosome secretion and tumor progression.

Pub. Date : 2019 Mar 1

PMID : 30824759






2 Functional Relationships(s)
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1 We revealed that the interaction between the SH3 domain of c-Src and the proline-rich region of Alix activates ESCRT-mediated intra-luminal vesicle (ILV) formation, resulting in the upregulation of exosome secretion in c-Src-transformed cells. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens
2 We revealed that the interaction between the SH3 domain of c-Src and the proline-rich region of Alix activates ESCRT-mediated intra-luminal vesicle (ILV) formation, resulting in the upregulation of exosome secretion in c-Src-transformed cells. Proline SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens