Title : Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo.

Pub. Date : 2019 Mar

PMID : 30815818






3 Functional Relationships(s)
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1 Antioxidant effects of ginkgolides and bilobalide against cerebral ischemia injury by activating the Akt/Nrf2 pathway in vitro and in vivo. Ginkgolides AKT serine/threonine kinase 1 Homo sapiens
2 Moreover, after ginkgolides and BB treatments, p-Akt and p-Nrf2 were significantly upregulated, which could be inhibited by LY294002 in a dose-dependent manner, meanwhile, GB exhibited more effective than GA and GK. Ginkgolides AKT serine/threonine kinase 1 Homo sapiens
3 Moreover, ginkgolides and BB upregulated the levels of antioxidant proteins through mediating the Akt/Nrf2 signaling pathway to protect neurons from oxidative stress injury. Ginkgolides AKT serine/threonine kinase 1 Homo sapiens