Title : The Importance of Detail: How Differences in Ligand Structures Determine Distinct Functional Responses in Integrin αv β3.

Pub. Date : 2019 Apr 23

PMID : 30811704






1 Functional Relationships(s)
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1 Inhibitors of integrin alphav beta3 are interesting anticancer agents but their molecular mechanisms are still unclear: Peptides and peptidomimetics characterized by the Arg-Gly-Asp (RGD) or isoAsp-Gly-Arg (isoDGR) binding motifs have shown controversial agonist/antagonist effects. arginyl-glycyl-aspartic acid integrin subunit alpha V Homo sapiens