Pub. Date : 2019 Apr 26
PMID : 30810041
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Research has suggested that the upregulation of ERK signaling by the anticancer agent paclitaxel leads to acquired resistance of cells to this compound. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 2 | Plumbagin was shown to decrease levels of phosphorylated ERK in breast cancer cells and abrogated paclitaxel-induced ERK phosphorylation. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 3 | The role of ERK in plumbagin-mediated sensitization of breast cancer cells to paclitaxel was shown through the enhancement of the synergistic effect between compounds in cells with decreased ERK expression. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 4 | The role of ERK in plumbagin-mediated sensitization of breast cancer cells to paclitaxel was shown through the enhancement of the synergistic effect between compounds in cells with decreased ERK expression. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |
| 5 | These results imply that plumbagin inhibits ERK activation in breast cancer cells, which plays a role in the sensitization of cells to paclitaxel-induced cell death. | Paclitaxel | mitogen-activated protein kinase 1 | Homo sapiens |