Pub. Date : 2019 Jun
PMID : 30808730
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Profiling of the metabolome demonstrates that suppression of CPS1 potentiates the effects of EGFR inhibition on central carbon metabolism, pyrimidine biosynthesis, and arginine metabolism, coinciding with reduced glycolysis and mitochondrial respiration. | pyrimidine | carbamoyl-phosphate synthase 1 | Homo sapiens |
| 2 | We show that EGFR inhibition and CPS1 knockdown lead to a decrease in arginine levels and pyrimidine derivatives, and the addition of exogenous pyrimidines partially rescues the impairment in cell growth. | pyrimidine | carbamoyl-phosphate synthase 1 | Homo sapiens |