Title : Pyrazoles containing thiophene, thienopyrimidine and thienotriazolopyrimidine as COX-2 selective inhibitors: Design, synthesis, in vivo anti-inflammatory activity, docking and in silico chemo-informatic studies.

Pub. Date : 2019 Apr

PMID : 30807897






1 Functional Relationships(s)
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1 Docking studies into COX-2 active site (PDB code 3LN1) revealed that compounds 3, 6a, 6c, 9, 10, 11 and 13 had binding modes and energies comparable to that of celecoxib. Celecoxib mitochondrially encoded cytochrome c oxidase II Homo sapiens