Pub. Date : 2019 Apr 1
PMID : 30802065
11 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Intracellular Activation of a Prostate Specific Antigen-Cleavable Doxorubicin Prodrug: A Key Feature Toward Prodrug-Nanomedicine Design. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 2 | It consists of doxorubicin (Dox) conjugated to a prostate specific antigen (PSA)-cleavable peptide that can be selectively activated by secreted PSA at the tumor site. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 3 | It consists of doxorubicin (Dox) conjugated to a prostate specific antigen (PSA)-cleavable peptide that can be selectively activated by secreted PSA at the tumor site. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 4 | It consists of doxorubicin (Dox) conjugated to a prostate specific antigen (PSA)-cleavable peptide that can be selectively activated by secreted PSA at the tumor site. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 5 | It consists of doxorubicin (Dox) conjugated to a prostate specific antigen (PSA)-cleavable peptide that can be selectively activated by secreted PSA at the tumor site. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 6 | It consists of doxorubicin (Dox) conjugated to a prostate specific antigen (PSA)-cleavable peptide that can be selectively activated by secreted PSA at the tumor site. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 7 | It consists of doxorubicin (Dox) conjugated to a prostate specific antigen (PSA)-cleavable peptide that can be selectively activated by secreted PSA at the tumor site. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 8 | In the present study, we have reported, for the first time, the intracellular activation of Dox-PSA, where Dox nuclear uptake was specific to C4-2B (PSA-expressing) cells, which agreed with the cytotoxicity studies. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 9 | In the present study, we have reported, for the first time, the intracellular activation of Dox-PSA, where Dox nuclear uptake was specific to C4-2B (PSA-expressing) cells, which agreed with the cytotoxicity studies. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 10 | This finding was confirmed by encapsulating Dox-PSA prodrug into pH-sensitive liposomes to enable prodrug intracellular release, followed by its enzymatic activation. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |
| 11 | Our approach could open the doors for novel Dox-PSA nanomedicines with higher safety and efficacy to treat advanced and metastatic prostate cancer. | Doxorubicin | kallikrein related peptidase 3 | Homo sapiens |