Title : Novel molecular mechanisms in the inhibition of adrenal aldosterone synthesis: Action of tolvaptan via vasopressin V2 receptor-independent pathway.

Pub. Date : 2019 May

PMID : 30801659






1 Functional Relationships(s)
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1 Notably, tolvaptan increased the levels of unfolded protein response (UPR) marker DDIT3 and eIF2alpha phosphorylation (a UPR-induced event), which could block the translation of CYP11B2 mRNA into protein and thereby inhibit aldosterone production. Tolvaptan DNA damage inducible transcript 3 Homo sapiens