Pub. Date : 2019 Oct
PMID : 30797877
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upregulated cyclin B1/CDK1 mediates apoptosis following 2-methoxyestradiol-induced mitotic catastrophe: Role of Bcl-XL phosphorylation. | 2-Methoxyestradiol | cyclin dependent kinase 1 | Homo sapiens |
| 2 | Earlier we showed that 2-methoxyestradiol increases the level and activity of cyclin B1/CDK1, which subsequently induces mitotic prometaphase arrest. | 2-Methoxyestradiol | cyclin dependent kinase 1 | Homo sapiens |
| 3 | In the present study, we demonstrate that upregulation of cyclin B1/CDK1 is responsible for the increased phosphorylation of the anti-apoptotic proteins Bcl-2 and Bcl-XL in 2-methoxyestradiol-induced, mitotically-arrested cancer cells. | 2-Methoxyestradiol | cyclin dependent kinase 1 | Homo sapiens |
| 4 | Together, these results indicate that cyclin B1/CDK1 upregulation in cancer cells undergoing 2-methoxyestradiol-induced mitotic catastrophe causes apoptosis via Bcl-XL phosphorylation. | 2-Methoxyestradiol | cyclin dependent kinase 1 | Homo sapiens |