Title : Author's view: epithelial plasticity metabolically reprograms normal cells towards a neoplastic-prone state.

Pub. Date : 2019

PMID : 30788419






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1 We have uncovered that epithelial plasticity programs metabolically reprogram epithelial lung cells by increasing expression of genes (e.g., glutamine-fructose-6-phosphate transaminase 2 - GFPT2 and UDP-N-acetylglucosamine pyrophosphorylase 1 - UAP1) critical for the hexosamine biosynthetic pathway (HBP) and elevating global protein O-GlcNAcylation - a specific type of glycosylation. Hexosamines glutamine-fructose-6-phosphate transaminase 2 Homo sapiens