Title : New arylpiperazine derivatives with antidepressant-like activity containing isonicotinic and picolinic nuclei: evidence for serotonergic system involvement.

Pub. Date : 2019 Jun

PMID : 30783717






2 Functional Relationships(s)
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1 The antidepressant-like effects of the new compounds in the FST were prevented by pretreatment of mice with pCPA (serotonin depletor), (-)pindolol (mixed 5-HT1A/1B and beta-adrenergic antagonist), and WAY 100635 (selective 5-HT1A antagonist). Pindolol 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus
2 The antidepressant-like effects of the new compounds in the FST were prevented by pretreatment of mice with pCPA (serotonin depletor), (-)pindolol (mixed 5-HT1A/1B and beta-adrenergic antagonist), and WAY 100635 (selective 5-HT1A antagonist). Pindolol 5-hydroxytryptamine (serotonin) receptor 1A Mus musculus