Pub. Date : 2019 Feb 19
PMID : 30783087
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 2 | We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 3 | Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitochondria and its interaction with PYCR1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell proliferation. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |
| 4 | Our findings reveal a mechanoresponsive kindlin-2-PYCR1 complex that links mechano-environment to proline metabolism and signaling, and suggest a strategy to inhibit tumor growth. | Proline | pyrroline-5-carboxylate reductase 1 | Homo sapiens |