Title : PDE5A Suppresses Proteasome Activity Leading to Insulin Resistance in C2C12 Myotubes.

Pub. Date : 2019

PMID : 30774657






2 Functional Relationships(s)
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1 Results: PDE5A was demonstrated to negatively regulate insulin signaling, evidenced by the opposite effects on the suppression or enhancement of the insulin-stimulated Akt phosphorylation and 2-deoxy-D-glucose (2-DG) uptake in C2C12 myotubes, when PDE5A was overexpressed or knockdown, respectively. Deoxyglucose insulin Homo sapiens
2 Results: PDE5A was demonstrated to negatively regulate insulin signaling, evidenced by the opposite effects on the suppression or enhancement of the insulin-stimulated Akt phosphorylation and 2-deoxy-D-glucose (2-DG) uptake in C2C12 myotubes, when PDE5A was overexpressed or knockdown, respectively. Deoxyglucose insulin Homo sapiens