Title : Modafinil protects hippocampal neurons by suppressing excessive autophagy and apoptosis in mice with sleep deprivation.

Pub. Date : 2019 May

PMID : 30767208






2 Functional Relationships(s)
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1 KEY RESULTS: Modafinil improved learning and memory in sleep-deprived mice, associated with the inhibition of excessive autophage and apoptosis and an enhanced activation of the PI3K/Akt/mTOR/P70S6K signalling pathway in hippocampal neurons. Modafinil thymoma viral proto-oncogene 1 Mus musculus
2 In addition, modafinil suppressed the aberrant autophagy and apoptosis induced by rapamycin and reactivated PI3K/Akt/mTOR/P70S6K signals in HT-22 cells. Modafinil thymoma viral proto-oncogene 1 Mus musculus