Title : Indispensable role of β-arrestin2 in the protection of remifentanil preconditioning against hepatic ischemic reperfusion injury.

Pub. Date : 2019 Feb 14

PMID : 30765766






5 Functional Relationships(s)
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1 Using the rodent models of hepatic ischemia reperfusion injury both in wild type and TLR4 knockout (TLR4 KO) mice, we found that remifentanil preconditioning could inhibit the expression of TLR4 and reduce the inflammatory response induced by HIRI in wild type but not in TLR4 KO mice. Remifentanil toll-like receptor 4 Mus musculus
2 Using the rodent models of hepatic ischemia reperfusion injury both in wild type and TLR4 knockout (TLR4 KO) mice, we found that remifentanil preconditioning could inhibit the expression of TLR4 and reduce the inflammatory response induced by HIRI in wild type but not in TLR4 KO mice. Remifentanil toll-like receptor 4 Mus musculus
3 Using the rodent models of hepatic ischemia reperfusion injury both in wild type and TLR4 knockout (TLR4 KO) mice, we found that remifentanil preconditioning could inhibit the expression of TLR4 and reduce the inflammatory response induced by HIRI in wild type but not in TLR4 KO mice. Remifentanil toll-like receptor 4 Mus musculus
4 Using the rodent models of hepatic ischemia reperfusion injury both in wild type and TLR4 knockout (TLR4 KO) mice, we found that remifentanil preconditioning could inhibit the expression of TLR4 and reduce the inflammatory response induced by HIRI in wild type but not in TLR4 KO mice. Remifentanil toll-like receptor 4 Mus musculus
5 These data suggested that remifentanil could ameliorate mice HIRI through upregulating beta-arrestin2 expression, which may function as a key molecule in bridging opioid receptor and TLR4 pathway. Remifentanil toll-like receptor 4 Mus musculus