Pub. Date : 2019 Sep
PMID : 30765471
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dimeric ferrochelatase bridges ABCB7 and ABCB10 homodimers in an architecturally defined molecular complex required for heme biosynthesis. | Heme | ATP binding cassette subfamily B member 7 | Homo sapiens |
| 2 | In ABCB7-depleted cells, defective heme biosynthesis resulted from translational repression of ALAS2 by iron regulatory proteins and from decreased stability of the terminal enzyme ferrochelatase. | Heme | ATP binding cassette subfamily B member 7 | Homo sapiens |
| 3 | Our studies not only underscore the importance of ABCB7 for mitochondrial Fe-S biogenesis and iron homeostasis, but also provide the biochemical characterization of a multiprotein complex required for heme biosynthesis. | Heme | ATP binding cassette subfamily B member 7 | Homo sapiens |