Title : Broad IgG repertoire in patients with chronic rhinosinusitis with nasal polyps regulates proinflammatory IgE responses.

Pub. Date : 2019 Jun

PMID : 30763592






2 Functional Relationships(s)
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1 IgE-containing nasal polyp homogenates with or without IgG depletion were evaluated for their capacity to promote IgE-facilitated allergen presentation, basophil activation, and histamine release. Histamine immunoglobulin heavy constant epsilon Homo sapiens
2 Depletion of IgG from nasal homogenates resulted in an increase in CD23-mediated IgE-facilitated allergen binding to B cells but also enhanced FcepsilonRI-mediated allergen-driven basophil activation and histamine release. Histamine immunoglobulin heavy constant epsilon Homo sapiens