Pub. Date : 2019 Feb 12
PMID : 30759842
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Fourfold Filtered Statistical/Computational Approach for the Identification of Imidazole Compounds as HO-1 Inhibitors from Natural Products. | imidazole | heme oxygenase 1 | Homo sapiens |
| 2 | Imidazole scaffold is normally present in most of the classical HO-1 inhibitors and seems indispensable to the inhibitory activity due to its strong interaction with the Fe(II) of the heme group. | imidazole | heme oxygenase 1 | Homo sapiens |
| 3 | Different imidazole-based compounds were suggested by our methodology to be potentially active in inhibiting the HO-1, and the results have been rationalized by the bioactivity of the filtered molecules reported in the literature. | imidazole | heme oxygenase 1 | Homo sapiens |